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Vibroacoustic Therapy Systems

We write the physical code that cells are built to read.

Skelesound builds whole-body platforms that turn water into programmable mechanical force — a new category of precision mechanotherapy.

01 · CLINICIANS
The science & evidence
Mechanism of action, safety architecture, and the investigational program.
02 · INVESTORS
The opportunity
A defensible platform across large indication landscapes. Request the briefing.
03 · PARTNERS
Collaborate with us
Research sites, health systems, and strategic development partners.
The Platform

Three mechanical fields, delivered at once.

Not vibration, not a bath — a mechanical field generator that couples force to the whole body through water, from the skin down to the cytoskeleton.

MACRO
The Whirlpool
Rotational fluid shear strips the boundary layer off the skin. 72 exciters, 18–30 Hz.
MESO
Interference Lattice
144 phased ultrasound transducers form a moving 3D grid of pressure nodes.
MICRO
Cellular Microstrain
0.5–0.85 MHz deforms the membrane to trigger direct integrin activation.
Products

One platform, two form factors.

FLAGSHIP · WHOLE-BODY
SkeleDrum MK-IV
300-gallon immersion reactor, 100% surface coupling, closed-loop tuning.
FOCUSED · EXTREMITY
SonoLimb
Focused limb recovery at 3× energy density — clinic-ready, sealed, portable.
Insights

Field notes from the team.

All insights

Partner with us on the next language of medicine.

Investors, clinicians, and strategic partners — request a confidential briefing.

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For Clinicians

A software-defined recovery modality for your practice.

SkeleDrum and SonoLimb deliver programmable mechanical therapy in sessions your team can protocolize — a differentiated, non-invasive offering for sports medicine, orthopedics, rehabilitation, and longevity care.

WHY CLINICS ADOPT SKELESOUND
Clinical differentiation
A modality competitors don’t offer — a reason for referrals and premium recovery memberships.
Protocolized workflow
Preset programs and tiers let staff run consistent, repeatable sessions with minimal training.
Non-invasive & hands-free
No consumables, no drugs, no operator fatigue. One technician can oversee multiple sessions.
Expanding library
Software-defined programs grow over time — new protocols without new hardware.
A TYPICAL SESSION
01
Select protocol
Choose program & power tier from the library.
02
Immersion
Patient enters the SkeleDrum; the system couples.
03
Auto-tuned delivery
Closed loop adjusts in real time; 20–40 min.
04
Session report
Absorption & exposure logged to the record.
EXPLORED APPLICATIONS
Post-workout recovery · range of motion · tendon & fascia · joint lubrication · lymphatic drainage · sleep & stress
Wellness & performance uses. Clinical indications are investigational and not established.
SAFETY & CONTROL
Hardware-enforced limits, 41 °C thermal cutoff, medical-grade isolation, and sub-millisecond monitoring.
IEC 60601-1CLOSED-LOOP

Request a clinical evaluation

Site assessment, ROI model, and evaluation-unit placement for qualified partners.

Contact clinical team
For Investors

A new device category that treats the body with programmable force.

Skelesound is raising a Series A to advance the SkeleDrum platform toward first-in-human data, with wellness revenue underwriting the clinical program.

THE PROBLEM
Mechanotransduction is a proven biological lever with no precision delivery device.
THE PLATFORM
Three mechanical fields under sub-millisecond closed-loop control — a therapy library, not a single treatment.
THE MOAT
A golden-angle fractal field that never repeats, so tissue stays sensitive. Defensible IP.
TARGET INDICATION LANDSCAPE
Beachhead
Recovery & performance
~200M
Osteoporosis & bone
~20M
Oncology · adjunct
~3–5M
Autoimmune · SLE
Figures are global disease prevalence / incidence from public epidemiology, shown to illustrate addressable landscapes. Clinical indications are investigational research targets — not cleared or approved uses.
THE RAISE
Series A to reach first-in-human
Funds a clinical-grade SkeleDrum, the quality & regulatory foundation, and first safety data.
Request the data room
Confidential teaser, financial model, and technical diligence materials for accredited investors.
Request access
Not an offer to sell or a solicitation to buy any security. Any offering will be made only to accredited investors through definitive offering documents.
For Partners

Build the evidence base with us.

We collaborate with research institutions, health systems, and strategic development partners to study mechanotransduction and bring precision mechanotherapy to more patients.

Research institutions
Co-designed studies, device access, and shared data on mechanobiology and mechanotransduction.
Health systems
Evaluation deployments, integration pathways, and structured pilots with outcome tracking.
Strategic & distribution
Territory distribution, co-development, and commercial partnerships as the platform scales.

Explore a collaboration

Tell us about your institution and where our interests align.

Start a conversation
Insights · The Resonance Review

Field notes from the people building the platform.

A weekly, team-authored look at the science, the engineering, and the standards behind precision mechanotherapy — written by our scientists, engineers, and regulatory leads.

All Mechanobiology Engineering Notebook Evidence & Literature Regulatory & Standards Founder Essays
FEATURED · WEEKLY SIGNAL · MECHANOBIOLOGY

Why the body reads the pattern, not the number

A single frequency says almost nothing to a cell. The instruction lives in the whole mechanical signal — five variables, delivered together. Here’s why that reframing changes how we design every program.

AK
Dr. Ashwin Kalyandurg
Chief Medical Architect · Mar 14, 2026 · 8 min
Latest posts
UPDATED WEEKLY
ENGINEERING
NOTEBOOK
Holding resonance lock across changing tissue density
How the closed loop re-tunes 1,000 times a second to keep force landing where we intend.
NR
Nitin Ravichander
Mar 7 · 6 min
REGULATORY
& STANDARDS
What “investigational” means, and why we say it on every page
Honest language isn’t a disclaimer reflex — it’s how a real medical-device company earns trust.
DL
Dana Levin
Feb 28 · 5 min
MECHANO
BIOLOGY
Integrins, focal adhesion kinase, and the road to the nucleus
A guided tour of the cascade we’re engineering the input end of.
SO
Dr. Sofia Okafor
Feb 21 · 9 min
FOUNDER
ESSAY
Medicine works in chemistry. We decided to work in physics.
The origin of the mechanogenomics thesis, and why force deserves a delivery device.
AK
Dr. Ashwin Kalyandurg
Feb 14 · 7 min
EVIDENCE &
LITERATURE
What the low-intensity ultrasound literature does and doesn’t show
A measured read of the published record, and where our own studies need to go.
SO
Dr. Sofia Okafor
Feb 7 · 10 min
WRITTEN BY THE TEAM
AK
Dr. A. Kalyandurg
Chief Medical Architect
NR
Nitin Paul Ravichander
Engineering
RF
Raylan Fernandes
Engineering
SO
Dr. Sofia Okafor
Clinical & Science
DL
Dana Levin
Regulatory & Quality
The weekly signal
One rigorous post a week, straight to your inbox. No hype.
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All insights
MECHANOBIOLOGY · WEEKLY SIGNAL

Why the body reads the pattern, not the number

AK
Dr. Ashwin Kalyandurg
Chief Medical Architect
MAR 14, 2026
8 MIN READ

A single number — say, 28 Hz — tells a cell almost nothing on its own. It’s like trying to describe a piece of music by naming one note. The instruction a cell can actually act on lives in the whole mechanical signal: the pattern, not the value.

That reframing is the foundation of how we design every program at Skelesound. A valid biological command is defined across five variables delivered together — carrier frequency, envelope, intensity, duty cycle, and rotational shear — and it’s the relationship between them, over time, that a cell’s mechanosensors interpret.

The cell is listening for structure

Mechanosensitive machinery doesn’t respond to raw magnitude alone; it adapts. Present a constant stimulus and the response fades within minutes — the biological equivalent of stopping noticing a smell. What holds attention is a signal with structure that doesn’t become predictable.

“We’re not turning a dial up. We’re writing a sentence the cell already knows how to read.”

This is why our fractal approach matters: prime-frequency mixing and a golden-angle offset produce a field that never quite repeats, so tissue stays sensitized rather than habituating. The design goal isn’t more force — it’s a more legible one.

What this means for the platform

Because the signal is software-defined, each program is a specific pattern rather than a single setting. That’s what makes the platform a library, and why the same hardware can pursue very different goals as the evidence develops.

In the coming weeks, my colleagues on the engineering and mechanobiology teams will go deeper on how we hold that pattern stable inside a living, changing body — and how we know it’s landing where we intend.

Disclaimer. This article describes intended mechanisms of action under active investigation. The SkeleDrum and SonoLimb are investigational devices and have not been cleared or approved by the FDA. Nothing here is medical advice or a claim of clinical efficacy.
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partners@skelesound.com
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clinical@skelesound.com
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press@skelesound.com
HEADQUARTERS
Skelesound, Inc.
548 Mission Street
San Francisco, CA 94105
Legal · Privacy

Privacy Policy

Last updated: 2026 · Template

Skelesound, Inc. (“Skelesound,” “we,” “us”) respects your privacy. This policy explains what information we collect through this website, how we use it, and the choices you have.

Information we collect

We collect information you provide directly — such as your name, organization, email, and message when you request a briefing or subscribe to updates — and limited technical information (device, browser, and usage analytics) collected automatically to operate and improve the site.

How we use information

We use your information to respond to inquiries, provide requested materials, send communications you opt into, maintain security, and comply with legal obligations. We do not sell your personal information.

Sharing

We share information only with service providers who process it on our behalf under confidentiality obligations, or where required by law. Investigational-program data is handled under separate study agreements and applicable regulations.

Your choices

You may unsubscribe from communications at any time and may request access to, correction of, or deletion of your personal information by contacting us. Depending on your location, additional rights may apply.

Contact

Questions about this policy? Email privacy@skelesound.com.

This is a template for illustration and does not constitute legal advice. Have qualified counsel review and adapt before use.
Legal · Terms

Terms of Use

Last updated: 2026 · Template

These Terms govern your use of the Skelesound website. By accessing the site, you agree to these Terms. If you do not agree, please do not use the site.

No medical or investment advice

Content on this site is for informational purposes only. It is not medical advice, diagnosis, or treatment, and it is not an offer or solicitation to buy or sell any security. The SkeleDrum and SonoLimb are investigational and not FDA-cleared.

Intellectual property

All content, trademarks, and logos are owned by Skelesound or its licensors and may not be used without prior written permission. “Skelesound,” “SkeleDrum,” and “SonoLimb” are trademarks of Skelesound, Inc.

Disclaimers & limitation of liability

The site is provided “as is” without warranties of any kind. To the maximum extent permitted by law, Skelesound is not liable for damages arising from your use of the site.

Governing law

These Terms are governed by the laws of the State of Delaware, without regard to conflict-of-laws principles.

This is a template for illustration and does not constitute legal advice. Have qualified counsel review and adapt before use.
Legal · Accessibility

Accessibility Statement

Last updated: 2026 · Template

Skelesound is committed to making its digital experiences accessible to the widest possible audience, regardless of ability or technology.

Our standard

We aim to conform to the Web Content Accessibility Guidelines (WCAG) 2.1 Level AA. This includes sufficient color contrast, keyboard navigability, meaningful text alternatives, and clear structure.

Ongoing effort

Accessibility is an ongoing commitment. We regularly review the site and work to remediate issues as they are identified.

Feedback

If you encounter a barrier, please email accessibility@skelesound.com and we will make reasonable efforts to provide the information or functionality you need.

This is a template for illustration and does not constitute legal advice.
Legal · Safety

Important Safety Information

Last updated: 2026 · Template
INVESTIGATIONAL DEVICE
The Skelesound SkeleDrum and SonoLimb are investigational and have not been cleared or approved by the U.S. Food and Drug Administration. They are limited by law to investigational use.

Intended context

Statements on this site describe intended mechanisms of action under active investigation. They have not been established in controlled clinical trials and are not claims of safety or efficacy for any indication.

Engineering safeguards

The platform is designed with hardware-enforced limits — including a 41 °C thermal auto-shutdown, amplitude capped below the cavitation threshold, and medical-grade electrical isolation — engineered toward IEC 60601-1. Hardware limits are designed so they cannot be overridden in software.

General precautions

Use is limited to trained personnel under approved protocols. Contraindications, warnings, and precautions will be defined through the clinical and regulatory process. Always consult a qualified healthcare professional regarding your individual situation.

This information is provided as a template and does not constitute medical or legal advice.
About Skelesound

We’re making mechanotransduction a controllable clinical modality.

Where most medicine acts on chemistry, we work in physics — delivering shear, pressure, and strain as a precise, patterned signal the body already knows how to interpret.

MISSION
Make mechanotransduction a controllable, clinical modality — not an accident of exercise.
PROMISE
Precision force, delivered as a signal — measured, patterned, and repeatable.
PERSONALITY
Trustworthy · Precise · Frontier. Clinical calm with scientific conviction.
AK
Dr. Ashwin Kalyandurg, DO
CHIEF MEDICAL ARCHITECT · FOUNDER
“We are not just treating symptoms. We are rewriting the biological code of the human body.”
THE TEAM
NR
Nitin Paul Ravichander
Co-Founder · Engineering
RF
Raylan Charles Fernandes
Co-Founder · Engineering
DL
Dana Levin
VP, Regulatory & Quality
SO
Dr. Sofia Okafor
Clinical & Scientific Affairs
CAREERS

Build the platform with us.

We’re assembling the founding team across engineering, regulatory, clinical, and commercial. If precision mechanotherapy is the problem you want to work on, we’d like to meet you.

Senior Acoustics Engineer
Engineering · San Francisco / Hybrid
OPEN
Regulatory Affairs Lead
Regulatory · San Francisco
OPEN
Clinical Research Associate
Clinical · Remote (US)
OPEN
Don’t see your role? Introduce yourself
Newsroom

Announcements & press.

Official company news. For interviews or assets, contact press@skelesound.com.

MAR 2026
PRESS RELEASE
Skelesound closes Series A to advance the SkeleDrum platform
Funding accelerates the path to a clinical-grade system and first-in-human data.
FEB 2026
SCIENCE
Preclinical data on fractal signaling and integrin density
Early results support the anti-adaptation hypothesis behind the platform’s field design.
JAN 2026
REGULATORY
Pre-submission meeting requested with the FDA
Skelesound initiates formal regulatory dialogue ahead of first-in-human studies.
Media kit
Logos, product imagery, executive bios, and boilerplate.
Request media kit
The Platform

A mechanical field generator that speaks to tissue.

Skelesound turns water into programmable mechanical force — writing the physical signal cells are built to read, in the language of shear, pressure, and strain.

THREE SIMULTANEOUS MECHANICAL FIELDS
MACRO
The Whirlpool
Rotational fluid shear spins the water column, stripping the stagnant boundary layer off the skin. Flow, not vibration.
72 EXCITERS · 18–30 HZ
MESO
Interference Lattice
Phase-shifted ultrasound wavefronts overlap into a moving 3D grid of pressure nodes — massaging the matrix from the inside.
144 TRANSDUCERS · PHASED
MICRO
Cellular Microstrain
Ultrasound deforms the cell membrane and cytoskeleton hundreds of thousands of times per second, triggering integrin activation.
0.50–0.85 MHZ · DIRECT
THE SIGNAL

The body reads the pattern, not the number.

A single frequency says almost nothing on its own — like describing a song by one note. A valid biological command is the complete mechanical signal, defined across five programmable variables delivered together.

01
Carrier
0.50–0.85 MHz
Penetration depth & medium
02
Envelope
1–128 Hz
The rhythm — the message
03
Intensity
0.20–0.60 W/cm²
The volume of force
04
Duty Cycle
% ON / OFF
The punctuation
05
Rotational Shear
18–30 Hz
Macro water vortex
Carrier sets the medium — penetration depth and the microstrain environment. Envelope is the message — the rhythm that tells the cell what to do. It’s the relationship between the five, over time, that a cell’s mechanosensors interpret.
MECHANISM OF ACTION

Physical force becomes gene expression.

01 · INPUT
Force
Shear & pressure on the extracellular matrix.
02 · SENSOR
Integrin · FAK
Anchors flex → focal adhesion kinase fires.
03 · NETWORK
Cytoskeleton
Actin tension transmits the pull inward.
04 · CORE
YAP/TAZ → DNA
Nuclear translocation → gene expression.
SAFETY & ENGINEERING

A dialogue with tissue — and fail-safe by design.

CLOSED LOOP · < 1 MS
Read, echo, micro-tune
Piezoelectric sensors read tissue impedance and resonance 1,000× per second. As density changes, the system auto-tunes frequency to hold maximum absorption.
SAFETY · REDUNDANT
Limits in hardware, not software
41 °C thermal auto-shutdown, hardware-capped amplitude below the cavitation limit, and medical-grade electrical isolation.
DESIGNED TO IEC 60601-1
PROGRAM LIBRARY

A software-defined therapy library.

20
PROGRAMS · 5 TIERS
Recovery
Lymphatic drainage · Sleep induction · Stress reduction · Post-workout flush
Performance
Muscle priming · Range of motion · Metabolic dominance · Reaction time
Structural
Bone density · Fascia release · Cartilage support · Tendon repair
Clinical
INVESTIGATIONAL
Scar remodeling · Acute inflammation · Fibrosis · Neuropathy
Products

One platform, two form factors.

The same physics, delivered whole-body or focused to a single limb.

FLAGSHIP · WHOLE-BODY
SkeleDrum MK-IV

Whole-body immersion reactor. 72 rotational drivers and 144 ultrasound transducers coupled through 300 gallons of water. A 5 mm annular gap exploits the Venturi effect for 100% mechanical coupling.

300 gal
IMMERSION
4 kW
PEAK POWER
100%
COVERAGE
FOCUSED · EXTREMITY
SonoLimb

Targeted limb recovery. A cylindrical focused array concentrates SkeleDrum physics into a high-pressure sleeve at 3× energy density — sealed, portable, and clinic-ready for acute injury and post-op rehabilitation.

DENSITY
Sealed
ENCLOSURE
Portable
CLINIC-READY
SPECIFICATIONS · SKELEDRUM MK-IV
Carrier frequency0.50–0.85 MHz
Envelope frequency1–128 Hz
Rotational shear18–30 Hz
LF exciters72 · rotational
Ultrasound transducers144 · phased
Immersion volume300 gal · 1,135 L
Loop latency< 1 ms
Safety standardIEC 60601-1
Provisional specifications, engineering sample — subject to change. Investigational device; not FDA cleared or approved.
Evidence & Clinical Program

Honest about what’s proven, and what we’re proving.

Mechanotransduction is well-characterized biology. Skelesound’s specific clinical benefits are hypotheses under active investigation — here’s exactly where we stand.

REGULATORY STATUS
The SkeleDrum and SonoLimb are investigational devices, not cleared or approved by the FDA. Statements describe intended mechanisms and have not been established in controlled clinical trials.
DEVELOPMENT ROADMAP
NOW
Prototype
MK-IV bench system & closed loop demonstrated.
0–12 MO
Design Freeze
Clinical-grade build; QMS & IEC 60601-1.
12–24 MO
Pre-Sub & GLP
FDA pre-submission; GLP safety.
24–36 MO
First-in-Human
IDE feasibility; lead indication readout.
36 MO +
Pivotal & Clearance
Pivotal trial → De Novo / 510(k).
ACTIVE RESEARCH DIRECTIONS
STRUCTURAL & BONE
Bone & tissue regeneration
Mechanotransduction is an established bone-remodeling pathway: loaded collagen generates the piezoelectric charge that recruits osteoblasts. Our strongest mechanistic footing.
SONODYNAMIC · INVESTIGATIONAL
Sonodynamic therapy
An early-stage research direction exploring acoustic activation of sonosensitisers, motivated by the finding that some tumor cells are markedly softer than healthy tissue. Preclinical and investigational only.
RECOVERY & PERFORMANCE
Real-world evidence
Wellness and performance use is our beachhead — generating real-world usage and safety data that informs the clinical program.
PUBLICATIONS & DATA
Preclinical results and white papers will be posted here as they clear peer review. Qualified partners can request our current technical dossier.
Reviewing our evidence?
Clinicians and researchers can request the current technical and preclinical summary.
Request the dossier